Lipophilic Statins and Aldosterone Secretion

Lipophilic Statins Inhibit CD44 Fragmentation In Chondrocytes

Control of aldosterone secretion.

Much has been learned of the grosser aspects of the control of secretion of aldosterone, the major mineralocorticoid, in the 25 years since its isolation and characterization. There remains little doubt that the main components of the control system are adrenocorticotrophic hormone (ACTH), sodium and potassium status and, arguably the most important, angiotensin 11. Other factors may play a min...

Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects.

BACKGROUND Statins substantially reduce cardiovascular mortality and appear to have beneficial effects independent of their lipid-lowering properties. We evaluated the hypothesis that statin use may modulate the secretion of aldosterone, a well-known contributor to cardiovascular disease. METHODS AND RESULTS We measured adrenal hormones in 2 intervention studies. In study 1 in hypertensive su...

The control of aldosterone secretion.

SOME GENERAL CONSIDERATIONS Clinical There is evidence that increased secretion of aldosterone is a contributory cause of oedema occurring in kidney, liver and heart disease. The term ' contributory ' is used in the sense of implying that a number of factors act concurrently in the developed clinical state, and it would be unusual for oedema formation to be simply and commensurately attributabl...

Aldosterone secretion and primary and malignant hypertension.

After the synthesis of desoxycorticosterone (DOC), it became apparent that this corticosteroid, the physiological effects of which are concerned primarily with sodium and potassium metabolism, can produce a state of hypertension both in animals and in man (1, 2). The induced hypertension is dependent upon the administration of adequate amounts of dietary sodium, whereas the hypertensive state, ...